Organoid technologies

08 January 2026   While the human central nervous system (CNS) has often been modelled with organoids, progress in constructing the peripheral nervous system (PNS) has been relatively limited. Yet, the PNS plays a crucial role in communication between different areas of the body and the brain and dysfunction in PNS has been tied to a number of chronic diseases.   The PNS has two main subsystems, one of which is the autonomic nervous system, which automatically controls physio

27 January 2026   Despite important investment in biomedical research, the most common malignant adult brain tumor - glioblastoma (GBM) - remains largely refractory to existing treatments. Tumors can evade or suppress immunity through a variety of mechanisms, including antigen heterogeneity and  immunosuppressive signaling. Owing in large part to inter-species differences in the immune system and the tumor microenvironment (extracellular matrix composition, stromal cells beha

26 September 2025   Hepatotoxicity, including drug-induced liver injury (DILI), is a leading cause of patient attrition, drug development discontinuation  and post-marketing withdrawal , resulting in significant morbidity and mortality. Conversely to direct DILI, idiosyncratic DILI (iDILI) is caused by drugs with little or no intrinsic hepatotoxicity, is not dose-dependent, and occurs with a longer latency period. The majority of DILI cases encountered in the clinical setting

08 July 2025   Despite extensive biomedical research, disease-modifying treatments for human neurodevelopmental disorders such as autism spectrum disorder and schizophrenia are still lacking. Neurology and psychiatry are consistently the lowest success categories in drug development, with a 95-97% failure rate in clinical trials. Owing to inter-species differences in brain anatomy and physiology, animal models do not recapitulate human-specific molecular and cellular pathways