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A Paradigm Shift: Toward Human-Centric Research

Animal experimentation has long been the backbone of biomedical research, yet, poor human relevance and low predictivity of animal models of human diseases often hinder scientific progress.

With their unique advantages, human-based methods are actively transforming research, offering unprecedented insights into human biology.

Explore human diseases categorized per organ system to discover: ​

  • Why human-based in vitro methods are essential for your research area

  • How you could use these techniques to address gaps in knowledge

  • What breakthroughs they could empower you to achieve

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EXPLORE HUMAN DISEASES

Alzheimer's
disease

  • What is the clinical spectrum of Alzheimer's disease?

  • What do we know about the etiology of Alzheimer's disease?

  • How similar are human and animal nervous systems?

  • Face validity - How well do animal models replicate the human disease phenotype?

  • Construct validity - How well do the mechanisms of disease induction in animals reflect the currently understood disease etiology?

  • Predictive validity - How well do animal models predict safety and efficacy of therapies in patients?

  • Ethical validity - How well do animal experiments align with human ethical principles?

  • Intrinsic validity - How well do animal models capture the clinical heterogeneity of Alzheimer's disease?

  • Extrinsic validity -  How well does animal experimentation generate reliable and reproducible outcomes?

  • In Summary

  • How is Human-Based In Vitro the Answer for advancing biomedical research into Alzheimer's disease?

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