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Artistic illustration of the lab-in-the loop process of development of personalized medicine. It depicts a continuous cycle that starts with patient-derived cells and progresses through in vitro disease modelling, mechanistic studies, drug testing, and pharmacokinetics, results of which are fed into AI models to generate predictions about drug candidates and recommend tailored therapies.

Tech Frontiers

When ingenuity finds solutions to challenges, new frontiers are forged.

From vascularization of organoids to spatial multi-omics, new engineering breakthroughs are constantly redefining what's possible in human-based in vitro science.

This is where you'll stay up to date on technical advancements and how they enhance the human relevance of biomedical research.

© Sania Ristic 2026 — Licensed under CC BY‑NC‑ND 4.0

Organ-on-a-chip systems

Genetic Engineering Unlocks Organotypic Vascularization

Organoid technologies

Human sympathetic ganglion organoids support investigation of sympathetic innervation of target organs

Autologous human tumor-immune organoid model for patient-specific prediction of response to immunotherapy

Human liver sketched in black and white. A purple grid is situated on top of the liver. Each line of the grid represents the chronology of immune-mediated drug-induced liver injury (DILI) - exposure to a drug or a chemical compound, followed by formation of reactive metabolites, innate immune activation, adaptive immune activation, mitochondrial dysfunction, apoptosis, and necrosis.

Human liver sketched in black and white. A purple grid is situated on top of the liver. Each line of the grid represents the chronology of immune-mediated drug-induced liver injury (DILI) - exposure to a drug or a chemical compound, followed by formation of reactive metabolites, innate immune activation, adaptive immune activation, mitochondrial dysfunction, apoptosis, and necrosis.

Immune-competent human liver organoids model adaptive immunity-mediated idiosyncratic DILI

Stylized pink and orange tree with a bubble-like texture, stands against a pastel gradient background. The tree is composed of 6 groups of branches, representing a newly engineered 6 region brain organoid.

Stylized pink and orange tree with a bubble-like texture, stands against a pastel gradient background. The tree is composed of 6 groups of branches, representing a newly engineered 6 region brain organoid.

Multi-region brain organoids for unprecedented insights into human neurodevelopmental disorders

3D Tissue platforms

3D immuno-glial-neurovascular human brain platform for high-fidelity disease modelling

A person sketched in black and white colour holds their head, looking troubled. His thoughts are visually represented by blue lines that intersect chaotically, suggesting the person suffers from cognitive impairment related to Alzheimer's disease. Beneath his eyes, 6 abstract pattern lines of different blue shades progress toward him. These lines symbolize the 6 distinct hiPSC-derived cell lines that researchers have used to engineer a 3D immuno-glial-neurovascular human brain model for preclinical research into neurodegenerative disorders.

A person sketched in black and white colour holds their head, looking troubled. His thoughts are visually represented by blue lines that intersect chaotically, suggesting the person suffers from cognitive impairment related to Alzheimer's disease. Beneath his eyes, 6 abstract pattern lines of different blue shades progress toward him. These lines symbolize the 6 distinct hiPSC-derived cell lines that researchers have used to engineer a 3D immuno-glial-neurovascular human brain model for preclinical research into neurodegenerative disorders.

A stylized complex multi-layer shape, representing 3D bioprinted human tissues for biomedical research. At its center, in orange colour, are functional bioprinted pancreatic islets. The use of innovative computer vision and microscopy technology to obtain an adaptive, context-aware printing is symbolized by eyes situated at the periphery of the printed construct.

A stylized complex multi-layer shape, representing 3D bioprinted human tissues for biomedical research. At its center, in orange colour, are functional bioprinted pancreatic islets. The use of innovative computer vision and microscopy technology to obtain an adaptive, context-aware printing is symbolized by eyes situated at the periphery of the printed construct.

Adaptive and context-aware volumetric printing enhances functional relevance of 3D bioprinted human tissues

Bioprinting

Hybrid AI-in vitro platforms

A silhouette of young man is facing his computer twin. The individual on the left is a biological entity with a visible brain, holding his patient-derived brain organoid. The individual on the right is a circuit board figure in blue, holding a blue sphere. The image symbolizes complementary between a real-world patient and his digital twin.

A silhouette of young man is facing his computer twin. The individual on the left is a biological entity with a visible brain, holding his patient-derived brain organoid. The individual on the right is a circuit board figure in blue, holding a blue sphere. The image symbolizes complementary between a real-world patient and his digital twin.

Digital Human Twins: Transforming the Future of Human Health

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