Application Explorer
Missed that important publication? With an explosion in scientific literature on advanced in vitro methods, it's becoming increasingly difficult to keep up.
We select, analyze, and summarize key research findings, distilling them into structured summaries for easy and time-saving exploration of in vitro use cases.
Our curated database showcases context of use, opening up new research avenues.
Human-based methods
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Number of results
64
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Heart Organoids
CELL TYPE
Human iPSC line
CONTEXT OF USE
The ability of human heart organoids to recapitulate the pathophysiological features of pregestational diabetes-induced congenital heart disease| including higher frequence of arrhythmic events| reduction in beating frequency| and cardiomyocyte hypertrophy.
REFERENCE
Kostina A| Lewis-Israeli YR| Abdelhamid M| et al. ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development. Stem Cell Reports| Volume 19| Issue 3| P317-330| March 12| 2024. doi:10.1016/j.stemcr.2024.01.003
YEAR
2024
LINK
METHOD
Human Multi-Chamber Cardioids
CELL TYPE
Human iPSC line. Human PSC lines.
CONTEXT OF USE
The ability of the human cardioid platform to recapitulate the development of all major embryonic heart compartments (right and left ventricles| atria| outflow tract| atrioventricular canal) and to model the effects of internal and external factors (mutations| drugs) on congenital heart disease pathogenesis.
Related pathologies: Congentital heart disease.
Potential applications: Mechanistic studies; Target identification; Drug testing.
REFERENCE
Schmidt C| Deyett A| Ilmer T| et al. Multi-chamber cardioids unravel human heart development and cardiac defects. Cell| Volume 186| Issue 25| p5587-5605.e27| December 07| 2023. doi: 10.1016/j.cell.2023.10.030
YEAR
2023
LINK
METHOD
Microvascularised Cardiac Spheroids-on-a-Chip
CELL TYPE
Human iPSC. Human primary cells.
CONTEXT OF USE
The ability of the microvascularized cardiac spheroid-on-chip model to produce perfusable and functional cardiac spheroids| enhancing their physiological relevance for cardiotoxicity testing.
REFERENCE
Di Cio S| Marhuenda E| Haddrick M| Gautrot JE. Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Scientific Reports. 2024;14(1):3370. doi:10.1038/s41598-024-53678-w
YEAR
2024