Prof. Y. Nahmias' lab (HUJ) receives $1.5M Breakthrough Research Grant to emulate the process of human aging on a chip
Updated: Aug 12
28 July 2026
Professor, researcher and entrepreneur Yaakov Nahmias announced that his lab at the Hebrew University of Jerusalem received a prestigious $1.5M Breakthrough Research Grant from the Israel Science Foundation to emulate the process of human aging on a chip.
Treatments that specifically target the biological processes that play a role in age‑related human disorders represent a particularly promising avenue. Owing to numerous inter-species differences, including in lifespan, genetic background, immune system, and metabolism, the biology of aging in commonly used model organisms is not translatable to humans, resulting in high rate of clinical failures and missed opportunities to better understanding the specificities of human aging.
The project named "Real-Time Metabolic Tracking of Accelerated Microphysiological Aging in Human Organoids" will use sensor-integrated human organoids and advanced artificial intelligence tools to compare the aging trajectories observed in human organoids with data from Psifas Initiative for Precision Medicine, Israel’s national clinical-genomic database.
Prof. Nahmias is the founder of Tissue Dynamics, an AI-driven bionic human organoid drug development company that aimes to improve the probability of clinical success by leveraging human organoids, bionic sensors directly embedded in human microtissues, MechaniX software for reconstruction of metabolic networks and DynamiX advanced robotic automation platform. The integrated sensors for oxygen, glucose, lactate, and glutamine enable real time data acquisition, providing rapid and direct measurements of extracellular metabolic fluxes, like glycolysis or respiration, superior to other instruments in the field.
The project is estimated to last 5 years.
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