26 September 2025   Hepatotoxicity, including drug-induced liver injury (DILI), is a leading cause of patient attrition, drug development discontinuation  and post-marketing withdrawal , resulting in significant morbidity and mortality. Conversely to direct DILI, idiosyncratic DILI (iDILI) is caused by drugs with little or no intrinsic hepatotoxicity, is not dose-dependent, and occurs with a longer latency period. The majority of DILI cases encountered in the clinical setting

02 October 2025   Microvessels - capillaries and post‑capillary venules - are the smallest vessels in the circulation, with a cellular composition and thin-walled structure that enables nutrient exchange, oxygen delivery, waste removal, and immune‑cell trafficking between the blood and surrounding tissue cells. The absence of microvascular function is often cited as a major bottleneck of in vitro preclinical models, leading to tissue necrosis and limiting physiological releva