26 September 2025   Hepatotoxicity, including drug-induced liver injury (DILI), is a leading cause of patient attrition, drug development discontinuation  and post-marketing withdrawal , resulting in significant morbidity and mortality. Conversely to direct DILI, idiosyncratic DILI (iDILI) is caused by drugs with little or no intrinsic hepatotoxicity, is not dose-dependent, and occurs with a longer latency period. The majority of DILI cases encountered in the clinical setting